Chemical synthesis of oligosaccharides and their application in new drug research

Zhimin Lv (1) , Hongyu Liu (1) , Huifang Hao (1) , Faiz-Ur Rahman (1) , Yongmin Zhang (1, 2, 3)

1 Inner Mongolia University
2 IPCM - Institut Parisien de Chimie Moléculaire
3 Hainan Normal University [Haikou, China]

Oligosaccharides are the ubiquitous molecules of life. In order to translate human bioglycosylation into clinical applications, homogeneous samples of oligosaccharides and glycoconjugates can be obtained by chemical, enzymatic or other biological methods for systematic studies. However, the structural complexity and diversity of glycans and their conjugates present a major challenge for the synthesis of such molecules. This review summarizes the chemical synthesis methods of oligosaccharides, the application of oligosaccharides in the field of medicinal chemistry according to their related biological activities, and shows the great prospect of oligosaccharides in the field of pharmaceutical chemistry.

Mots clés: Biological Activity; Synthesis; Oligosaccharide; Glycosylation; Drug Research

Domaines: Chimie

Zhimin Lv, Hongyu Liu, Huifang Hao, Faiz-Ur Rahman, Yongmin Zhang. Chemical synthesis of oligosaccharides and their application in new drug research. European Journal of Medicinal Chemistry, 2023, 249, pp.115164. ⟨10.1016/j.ejmech.2023.115164⟩. ⟨hal-03978291⟩