Differences in thermal structural changes and melting between mesophilic and thermophilic dihydrofolate reductase enzymes

Irene Maffucci , Damien Laage (1) , Guillaume Stirnemann , Fabio Sterpone

1 PASTEUR - Processus d'Activation Sélective par Transfert d'Energie Uni-électronique ou Radiatif (UMR 8640)

The thermal resistance of two homolog enzymes is investigated, with an emphasis on their local stability and flexibility, and on the possible implications regarding their reactivity.

Domaines: Chimie

Irene Maffucci, Damien Laage, Guillaume Stirnemann, Fabio Sterpone. Differences in thermal structural changes and melting between mesophilic and thermophilic dihydrofolate reductase enzymes. Physical Chemistry Chemical Physics, 2020, 22 (33), pp.18361-18373. ⟨10.1039/d0cp02738c⟩. ⟨hal-04005920⟩