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Article Dans Une Revue (Article De Synthèse) Trends in Microbiology Année : 2022

Adaptations of intracellular bacteria to vacuolar or cytosolic niches


Invasive bacteria colonise their host tissues by establishing niches inside eukaryotic cells, where they grow either in the cytosol or inside a specialised vacuole. These two distinct intracellular lifestyles both present benefits but also impose various constraints on pathogenic microorganisms, in terms of nutrient acquisition, space requirements, exposure to immune responses, and ability to disseminate. Here we review the major characteristics of cytosolic and vacuolar lifestyles and the strategies used by bacteria to overcome challenges specific to each compartment. Recent research providing evidence that these scenarios are not mutually exclusive is presented, with the dual lifestyles of two foodborne pathogens, Listeria monocytogenes and Salmonella Typhimurium, discussed in detail. Finally, we elaborate on the conceptual implications of polyvalence from the perspective of host-pathogen interactions.
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hal-03602380 , version 1 (25-08-2022)



Thomas J.P. Petit, Alice Lebreton. Adaptations of intracellular bacteria to vacuolar or cytosolic niches. Trends in Microbiology, 2022, 30 (8), pp.736-748. ⟨10.1016/j.tim.2022.01.015⟩. ⟨hal-03602380⟩
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