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Role of angiotensin III in hypertension

Annabelle Reaux-Le Goazigo 1 Xavier Iturrioz 1 Céline Fassot 1 Cédric Claperon 1 Bernard Roques 1 Catherine Llorens-Cortes 1
1 Neuropeptides centraux et régulations hydrique et cardiovasculaire
UPMC - Université Pierre et Marie Curie - Paris 6, INSERM - Institut National de la Santé et de la Recherche Médicale : U691, CIRB - Centre interdisciplinaire de recherche en biologie
Abstract : The hyperactivity of the brain renin-angiotensin system (RAS) has been implicated in the development and maintenance of hypertension in several types of experimental and genetic hypertension animal models. Among the main bio-active peptides of the brain RAS, angiotensin (Ang) II and Ang III display the same affinity for type 1 and type 2 Ang II receptors. Both peptides, injected intracerebroventricularly, similarly increase blood pressure (BP); however, because Ang II is converted in vivo to Ang III, the identity of the true effector is unknown. In this article, we review new insights into the predominant role of brain Ang III in the control of BP, underlining the fact that brain aminopeptidase A (APA), the enzyme-forming central Ang III, could constitute a putative central therapeutic target for the treatment of hypertension. This justifies the development of potent systemically active APA inhibitors, such as RB150, as prototypes of a new class of antihypertensive agents for the treatment of certain forms of hypertension.
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Contributeur : Céline Fassot <>
Soumis le : lundi 10 mai 2021 - 16:55:07
Dernière modification le : vendredi 4 juin 2021 - 03:24:13


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Annabelle Reaux-Le Goazigo, Xavier Iturrioz, Céline Fassot, Cédric Claperon, Bernard Roques, et al.. Role of angiotensin III in hypertension. Current Hypertension Reports, Current Medicine Group, 2005, 7 (2), pp.128-134. ⟨10.1007/s11906-005-0087-z⟩. ⟨hal-02524845⟩