Exosome-mediated quality control: substrate recruitment and molecular activity - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue (Article De Synthèse) BBA - Biochimica et Biophysica Acta Année : 2008

Exosome-mediated quality control: substrate recruitment and molecular activity

(1) , (1)
1

Résumé

The eukaryotic exosome is a multisubunit complex that is mainly responsible for 3'-5' exonucleolytic degradation of RNAs, both in the nucleus and the cytoplasm. In this review we summarize the recent experiments that have provided information on the organisation, structure and activity of this large assembly. Interestingly, eukaryotic exosomes have been implicated in a large number of RNA degradation pathways including recently discovered RNA quality control mechanisms. A variety of cofactors have been shown to participate in substrate recruitment and/or assist exonucleolytic activities. Despite this avalanche of new results, further analyses will be required to improve our understanding of exosome regulation.
Fichier principal
Vignette du fichier
BBA_post-print.pdf (806.96 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-01350691 , version 1 (03-08-2016)

Identifiants

Citer

Alice Lebreton, Bertrand Séraphin. Exosome-mediated quality control: substrate recruitment and molecular activity. BBA - Biochimica et Biophysica Acta, 2008, 1779 (9), pp.558-65. ⟨10.1016/j.bbagrm.2008.02.003⟩. ⟨hal-01350691⟩
155 Consultations
430 Téléchargements

Altmetric

Partager

Gmail Facebook Twitter LinkedIn More