A functional network involved in the recycling of nucleocytoplasmic pre-60S factors

Abstract : Eukaryotic pre-ribosomes go through cytoplasmic maturation steps before entering translation. The nucleocytoplasmic proteins participating in these late stages of maturation are reimported to the nucleus. In this study, we describe a functional network focused on Rei1/Ybr267w, a strictly cytoplasmic pre-60S factor indirectly involved in nuclear 27S pre-ribosomal RNA processing. In the absence of Rei1, the nuclear import of at least three other pre-60S factors is impaired. The accumulation in the cytoplasm of a small complex formed by the association of Arx1 with a novel factor, Alb1/Yjl122w, inhibits the release of the putative antiassociation factor Tif6 from the premature large ribosomal subunits and its recycling to the nucleus. We propose a model in which Rei1 is a key factor for the coordinated dissociation and recycling of the last pre-60S factors before newly synthesized large ribosomal subunits enter translation.
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Alice Lebreton, Cosmin Saveanu, Laurence Decourty, Jean-Christophe Rain, Alain Jacquier, et al.. A functional network involved in the recycling of nucleocytoplasmic pre-60S factors. Journal of Cell Biology, Rockefeller University Press, 2006, 173 (3), pp.349-60. 〈http://jcb.rupress.org/content/173/3/349.long〉. 〈10.1083/jcb.200510080〉. 〈hal-01350674〉

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