Electrode‐supported and free‐standing bilayer lipid membranes: Formation and uses in molecular electrochemistry

Eric Labbé (1) , Olivier Buriez (1)

1 PASTEUR - Processus d'Activation Sélective par Transfert d'Energie Uni-électronique ou Radiatif (UMR 8640)

This short review is aimed at emphasizing the recent most prominent advances in the electrochemical investigation of the interactions of molecules with purely lipid bilayers. The first part which deals with electrode-supported bilayer lipid membranes is articulated around the nature of electrode material with a focus on mercury to celebrate this special issue entitled "100 years from polarography to contemporary electrochemistry". The second part is devoted to suspended or free-standing bilayer lipid membranes that are robust models to investigate the passive transport of molecules. It is notably shown that molecular electrochemistry methods such as cyclic voltammetry, square wave voltammetry, amperometry, electrochemical impedance spectroscopy, or electrochemiluminescence are well-adapted for the investigation of molecules/lipids interactions or the passive transport of molecules. These various techniques bring meaningful information notably on molecule/lipid interactions and transport modes across phospholipids.

Mots clés: artificial membranes; bilayer lipid membranes; molecule lipid interaction; molecular electrochemistry; passive transport

Domaines: Biochimie, Biologie Moléculaire

Eric Labbé, Olivier Buriez. Electrode‐supported and free‐standing bilayer lipid membranes: Formation and uses in molecular electrochemistry. Electrochemical Science Advances, inPress, pp.e2100170. ⟨10.1002/elsa.202100170⟩. ⟨hal-03510446⟩